Sunday, December 27, 2020

vision preservation, long life online research. Carle Illinois College of Medicine

Alan,

I now have more than 50 years of full time computer experience and have returned to printing out almost everything as I did prior to 2010 when I started using screens more.

My teenage vision is returning as I use screens less and paper more.
I rarely wear prescription lenses now.
I walk 20-30 hours per day outdoors or looking out windows.
I thought I was going blind 7 years ago after 1 year intense reading on Apple retina display reading hours per day tiny ipod touch 4 retina display.
Eyes craved sun, I had to go outside in bright sun no sunglasses.
Red wavelengths from the sun are an anti-oxidant for the retina.
Blue wavelengths from electronics are a pro-oxident destroys the retina over time.

Printed pages almost always are readable in standard size.
Computer screens almost always need resizing, or too faded, or jiggly,...

100 dots per inch is the best you can hope for on a computer,
usually closer to 10 on bloatware browsers designed by idiots.

1000 dots per inch on a cheap laser printer.

10000 dots per inch for quality books, steel typewriters….

Trillions of dots per inch for Kodak black/white photographs.

I get the pdf of online articles and print them out on my 10 year old laser printer $100 at Walmart...
Toner is cheap - $15 per cartridge Amazon.com.
Paper is cheap

Printed papers and books is almost always readable, no ads, no popups, no spying, no music, no videos...

Difficult math and science articles and books can take months to understand,
so you don't need much paper.

For skimming and staying current go the library.
Library is 100 times faster than anything online.
Print out the online paper for what you cannot check out or just read in the library.

There is a huge amount of tracking every activity you do online, infuriating.

One way I can fight is by real paper, library browsing, thinking, turning off the electronics,...

https://en.wikipedia.org/wiki/Dots_per_inch#Computer_monitor_DPI_standards

Since the 1980s, the
Microsoft Windows operating system has set the default display "DPI" to 72 PPI,
while Apple/Macintosh computers have used a default of 96 PPI

From: Alan

Joe,

I like reading on a computer screen because I can make the text as large and bright as I want.

I can search through research articles on PubMed quickly and find what I want. The abstracts are always available and maybe 30% of the time the entire article is free.

I think the greatest source of disinformation is the 'news' spread on social media. There are no standards for what someone will post or forward. I only go on Facebook a couple of times a month.

My 5 day water fast was competed Friday. I dropped 8 lbs. It took about 36 hours after the fast to come back up to my normal energy level.

Alan

On Dec 20, 2020, at 5:57 AM, joe
wrote:

Alan,

Beware of China funded research
promoting Pills from communist China.

Beware of
TV idiot box,
computer moron box,
radio imbecile box,
Disinformation funded by advertising.

You need 8 hours per day of physical exercise.
Also 8 hours per day of mental exercise.
Get an MD for brain exercise -
learn how to make your body survive.

You need access to hundreds of laboratory devices to study your own body.
And a lot of classes and classmates and teachers
to teach you how to use the machines
and understand the measurements.

All doctors learned from
real paper text books and journals
and real people in-person classes.
Constant verbal interactions with students, doctors, and patients.
Same for all professions, for thousands of years.

The reading of scientific articles is harder,
requires more machines and more books and journals.
You cannot understand any particular article without the context and a detailed knowledge of the field.

Most articles are hidden behind paywalls,
but can be found on paper in the libraries.
Easier to just study in the library instead of printing out pdfs at home.
Can flip thru 100 articles in a few hours per day to find the best article on a subject.
Online is extremely show and invested with communists, ads, spyware, hackers,…

100 dots per inch versus 1000 or 10000 dots per inch.
Save your eyes.

If you get student status you access to both online and library materials,
and most importantly the knowledge on how to read and understand the articles.

joe wrote:

Engineer your body to stay healthy
120 years or more

https://medicine.illinois.edu/admissions/

From: Alan
Admissions - Carle Illinois College of Medicine

Joe,

I think that I can get a broader exposure to medical research from around the world by using the internet and staying independent.

Here is a research article about a new drug that reverses brain damage and dementia that I read yesterday:

https://elifesciences.org/articles/62048

Alan

Small molecule cognitive enhancer reverses age-related memory decline in mice

With increased life expectancy, age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease.

The integrated stress response (ISR) is activated during aging and contributes to age-related brain phenotypes.

We demonstrate that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicated by decreased levels of activating transcription factor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2.

Furthermore, ISRIB treatment reverses spatial memory deficits and ameliorates working memory in old mice.

At the cellular level in the hippocampus, ISR inhibition (i) rescues intrinsic neuronal electrophysiological properties, (ii) restores spine density and (iii) reduces immune profiles, specifically interferon and T cell-mediated responses.

Thus, pharmacological interference with the ISR emerges as a promising intervention strategy for combating age-related cognitive decline in otherwise healthy individuals.

"Of the capacities that people hope will remain intact as they get older, perhaps the most treasured is to stay mentally sharp"

The impact of age on cognitive performance represents an important quality-of-life and societal concern, especially given our prolonged life expectancy.

While often discussed in the context of disease, decreases in executive function as well as learning and memory decrements in older, healthy individuals are common

the aging population is estimated by 2050 to reach 83.7 million individuals above 65 years of age in the US; this represents a rapidly growing healthcare and economic concern

Age-related decline in memory has been recapitulated in preclinical studies with old rodents

Specifically, prior studies have identified deficits in spatial memory
working and episodic memory
and recognition memory (Cabral-Miranda et al., 2020),
when comparing young, adult mice with older sex-matched animals.

The hippocampus is the brain region associated with learning and memory formation and is particularly vulnerable to age-related changes in humans and rodents (Disterhoft and Oh, 2007; McKiernan and Marrone, 2017; Oh et al., 2010; Rizzo et al., 2014).

Deficits in a number of cellular processes have been suggested as underlying causes based on correlative evidence, including

protein synthesis (Schimanski and Barnes, 2010),

metabolism (Azzu and Valencak, 2017),

inflammation (Franceschi et al., 2000), and

immune responses (Villeda et al., 2011; Villeda et al., 2014; Baruch et al., 2014; Dulken et al., 2019).

While providing a wealth of parameters to assess, by and large the causal molecular underpinnings of age-related memory decline have remained unclear.

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