Sunday, November 17, 2019

age 110 immune system

Dear Professor Kaufman,

Flu, colds, pneumonia are big danger to elderly.
Immune system important for survival.
Must be balanced, not too weak or too strong.
Weak immune system allows germs to cause diseases, cancer to flourish,….
Too active causes autoimmune disease, inflammation,….

Diet is very important, probiotics feed the gut microbiome, big part of the immune system.
Eat fermented foods, probiotics, "live cultures" the foundation of the immune system.
Yogurt important fermented food readily available, I have used yogurt since 1967
Too Good brand is 2% lactose.
Oikos triple zero is 0% lactose.
Plain Dannon is #1 world seller my most common.
Avoid additives of any sort in yogurt often poisoned with sugar, colors, chemicals from Communist China.
Plain the best.

Zinc is very important for immune system.
Zinc deficiency is common.
Oysters by far the best source of zinc.
Move to Texas or Florida and harvest fresh yourself or buy from store.
Walmart Polar Brand yellow can is from Korea, our ally and dependent.
Avoid any brand from Communist China.

Brazil nuts another good source of zinc.
Buy in shell raw, crack it yourself guaranteed fresh no additives.
You cannot eat too many nuts in the shell.
Nuts are very healthy.

Natto a very healthy fermented soy food, find in Asian Grocery stores refrigerated "live" why Japanese the longest life people in the world.
Builds immune system and is the best source of Vitamin K by far.
Vitamin K takes calcium out of arteries where it is unhealthy
and deposits calcium in the bones where it is needed to prevent fractures.
Very important for older people.
Tastes strange but can get used to natto, stringy, bland but very healthy.

Protect vision:
Add pumpkin to hot coffee, and cinnamon, ginger, other spices.
Helps cut acid and improves taste.
Bright yellow pumpkin is important for eye health.

Eat 1 raw carrot with each meal for eye health.
Slice and add bright yellow French's mustard.
Can wrap in a slice of toast with mayonnaise.
Bright yellow and dark green good for eye health, and berries.

Fish oil important to neurological health and anti-inflammatory.
Canned fish the best source of fish oil, not from Communist China.
I insist on North America or Europe.

Put sesame seeds in hot coffee, let them soften and chew carefully.
Sesame oil goes with fish oil for neurological health and anti-inflammatory properties.

Learn to make real sauerkraut at home.
Another source of live cultures for immune system.

Also kefir milk you can brew at home maybe easier than sauerkraut.
Or buy in store.
But I prefer yogurt, more popular, common.

Immune system very important as flu season approaches.
Lots of hacking, coughs around here already.

The secret to living past 110 may be an increase in killer cells in the bloodstream.

New research finds that "supercentenarians," or people who make it to 110 years of age or older,

have higher-than-typical concentrations of a particularly rare type of T helper cell in their blood.

These immune cells might protect the oldest of the old against viruses and tumors,
leaving them in remarkably fine health throughout their long life spans.

"The key will be to understand what is [the cells'] their natural target,
which may help to reveal what is needed for a healthy, long life,"
study co-authors Kosuke Hashimoto, Nobuyoshi Hirose and Piero Carninci wrote in a joint email to Live Science.

Related: 11 Surprising Facts About the Immune System

Secrets of supercentenarians

Carninci and Hashimoto are both researchers at the Riken Center for Integrative Medical Sciences in Japan,
while Hirose is a scientist at the Centre for Supercentenarian Medical Research of the Keio University School of Medicine in Tokyo.

They and their colleagues wanted to analyze the immune cells of supercentenarians because it had never been done before.

People who live past 110 are rare even in Japan,
where longevity is common and life expectancy reached over 81 years for men and over 87 years for women in 2018, according to government statistics.

Japan's 2015 census found that there were 61,763 people 100 years old or older living in the country that year, but only 146 who were 110 or older.

The researchers isolated immune cells from the blood of seven supercentenarians and five control participants, ranging in age from their 50s to their 80s.

The scientists then used an advanced method called single-cell transcriptomics to find out what each of the immune cells was doing — individually.

This method measures the messenger RNA produced by the hundreds of thousands of genes within a cell.

Messenger RNA is the go-between that translates the genetic instructions of DNA to the nucleus of the cell,
which uses those instructions to build proteins.

By essentially reading the messages of the messenger RNA,
researchers can determine the activities of each cell,
effectively identifying it and its function.

Immune protection

The samples netted more than
41,000 immune cells from the seven supercentenarians and nearly
20,000 more from the younger control subjects.

a large proportion of the supercentenarians' immune cells were from a subset called

CD4 CTLs, a kind of T helper cell that can directly attack and kill other cells.

"This is surprising, because they are generally a rare cell type,"

The broad group of CD4 cells, or T helper cells, are generally not fighters.

These cells are more like commanders,
telling other immune cells what to do by releasing inflammatory chemicals called cytokines.

But CD4 CTLs are cytotoxic,
meaning they're capable of actually attacking and destroying invaders themselves.

Usually just a few percent of all T helper cells are cytotoxic;
the younger people in the new study showed an average of just 2.8%.

in the supercentenarians, about 25% of all helper Ts consisted of this deadly version,

Cytotoxic T cells have been shown to attack tumor cells and protect against viruses in mice,

"One may expect to find some cancer antigens or some virus protein

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