Wednesday, May 30, 2018

intergenerational trauma native - Google Search

air pollution auto exhaust

I may have a leak somewhere in exhaust.
Any driving can expose you to exhaust from the cars in front of you and nearby.
Generally in smoggy areas you can be damaged.
I think that lungs are my weak link, from much exposure to smog over the years, and then mold in San Francisco and humboldt.
Got out of the smog 1967 mostly before too many heavy metals accumulated.
looking to detox if any left in me.

Tuesday, May 29, 2018

Jennifer Pharr Davis - 46 day hike record

Jennifer Pharr Davis - Wikipedia
47 miles per day
36 bears

Jennifer Pharr Davis

Jennifer Pharr Davis is an American long distance hiker, author, speaker, National Geographic Adventurer of the Year, and Ambassador for the American Hiking Society.[1] She has hiked over 12,000 miles on six different continents, including thru-hikes on the Pacific Crest Trail, the Appalachian Trail (three times), the Colorado Trail, the Long Trail in Vermont, the Bibbulmun Track in Australia, and numerous trails in Europe and South America (e.g., the Tour du Mont Blanc, West Highland Way, Laugavegur, GR 11 (Spain), GR 20, and the Pembrokeshire Coast Path, Cotahuasi Canyon and the Inca Trail to Machu Picchu).

Jennifer Pharr Davis
Born May 25, 1983 (age 34)
Hendersonville, North Carolina
Nationality American
Other names "Odyssa"
Occupation Author, Speaker, Hiker, Founder and Owner of Blue Ridge Hiking Company (Asheville, NC)
Known for Long Distance Hiking

In 2011, Pharr Davis set the unofficial record for the fastest thru-hike of the Appalachian Trail with a time of 46 days, 11 hours, and 20 minutes, an average of 47 miles (76 km) a day, a record she held for four years until July 12, 2015, when Scott Jurek finished 3 hours and 12 minutes faster.[2][3][4] Pharr Davis lives in Asheville, North Carolina with her husband Brew and their daughter Charley.[3] She attended the Asheville School.[5] She first hiked the Appalachian Trail in 2005 after graduating from Samford University.[2] To prepare for her initial hike, she attended a class taught by Warren Doyle at the Appalachian Trail Institute. In 2008, she set the record for the fastest Appalachian Trail hike by a woman, in 57 days and 8 hours, an average of 38 miles (61 km) per day. She had previously set the Long Trail trail record in 7 days and 15 hours in 2007. She also established the fastest known time on the Bibbulmun Track in Western Australia in 2008.[2]

Pharr Davis has written two guidebooks about hiking in the Charlotte, North Carolina area, and one about hiking near Asheville, North Carolina. She has also written two memoirs- 2010's Becoming Odyssa, about her 2005 Appalachian Trail thru-hike,[3][6] and 2013's Called Again, about her record setting A.T. hike.

As a member of the National Speakers Association, Pharr Davis has shared her trail lessons hundreds of time all across the country, including presentations to Fortune 500 companies, trade organizations, colleges and universities, K-12 schools, libraries, festivals, churches, and other non-profits. She has been featured in the New York Times, the Washington Post, NPR's Talk of the Nation, and The Early Show on CBS. Her articles have appeared in print and online editions for Outside Magazine, Trail Runner, and Blue Ridge Outdoors, and she has contributed to articles in Men's Journal, National Geographic Adventure, and Backpacker.

In 2008, Pharr Davis founded Blue Ridge Hiking Company, with the belief that "the trail is there for everyone at every phase of life" and with the goal of getting people- especially women and children- outdoors on their own terms. The company leads half-day, full day and overnight trips in the Blue Ridge Mountains surrounding Asheville.[7] Pharr Davis is an ambassador for the American Hiking Society, and she was featured as one of National Geographic's Adventurers of the Year in 2012. She was also named Blue Ridge Outdoors Magazine's Person of the Year in 2008, and her record-setting A.T. hike in 2011 was named "Performance of the Year" by Ultrarunning Magazine. She has hiked with her husband and young daughter in all fifty states and she is currently hiking the Continental Divide Trail in sections through the Rocky Mountains.[8][9][10]


External links

sandals: George Gurdjief Fwd: grow brain by exercise

I walked more than 74 miles in 3 days while reading books.
More than that including shopping, errands, etc.
Spring cleaning too.
I get sore feet and somewhat sore muscles.
Vitamin C helps reduce inflammation.
Whey protein I have not had red meat this year.
Change shoes several times per day.
I discovered Dr. Scholes memory foam sandals ok for sit in class, libraries, and low mileage.
Cooler and hits feet in fewer but better places.
But not good for running, SHTF.
I always thought I should try to wear something that I could run 26 mile marathon in case SHTF.
There are lots of flip flops etc maybe should try.

Low blood pressure is not a problem - it will not happen without serious disease.
High blood pressure is a huge problem that accompanies other serious diseases particularly metabolic syndrome 
(obesity, diabetes, cancer, arthritis, dementia, high blood pressure) from sugar, salt, flour, vegetable oils and lack of exercise.
Syndrome causes high blood pressure and inflames and weakens the veins and arteries so they burst - strokes, heart attacks.
You want clean flexible pipes.  
If pipes get clogged from inflammatory substance build up then you get a heart attack.
If pipes stiff rigid thin brittle straws they can burst open such as when cleaning snow off the driveway..
Hard weightlifting can double or triple your blood pressure briefly.
You are supposed to exhale when lifting and shout or your heart will stop.
To prepare for SHTF you must stay in shape.
I was reading statistics that said that more soldiers died from flu than guns in WWI.
Iran lost 25% of its population.
Mexico and poor rural countries hurt worse.
Small villages in Alaska completely killed off.
USA lost 5% of its population, even young healthy people gone in a few hours.
Started in Kansas chicken hog farms brought in by the avian flyway 1918.
Mostly unpopulated area but some Mexican butchers have moved in.
Huge amounts of disease comes in thru animals, ticks, mosquitos, parasites …
- science of Zoonoses.
I live in the middle of a city and have seen no wildlife, but are a few dogs, cats, etc.
Have not been outside of city limits for 18 months


Examine the belief and training system of George Gurdjief (1866?-1949).
Armenian/Greek philosopher / mystic.
Gudjief believed one could only reach a higher unified consciousness through difficult and vigorous exercise routines. 
He toured the world with his team's of students. 
These students were taken from ordinary persons.
They had been trained to perform difficult intellectual and dance feats.



Also avoid LOW BP, as dangerous as HIGH. 
When your diastolic drops to 60's you will notice fuzzy thinking, difficulty concentrating, and sleepiness. 
So many elderly died in hot tubs after a glass of wine (vasodilator) - kinda like boiling frogs, huh?



Grow your brain by daily exercise.
I have long felt I could think more clearly while running or walking, getting blood to the brain.
Grow muscles by exercising.
Grow brain by thinking.
Turns out that exercising and thinking work together to grow brain and body.
Must keep all fluids moving in body to get nutrients to all cells and clear out wastes.
The body / brain system is designed for work by the sweat of your brow, not sedentary, driving, TV, movies .

First thing in the morning do the most important things first to prioritize your day.
Get hydrated - coffee, tea or whatever plus vitamin C, eggs, whey - and check email and news.
Then out the door, to the gym or any place you can walk preferably in the sun.
It takes about 6 hours for a proper workout.
Then it is time for lunch.
Then off to work.

This study shows loss of over half of brain in a month of partially restricted motion.
Explains why most modern high school graduates nowadays suffer from dementia, Alzheimers, Autism, ADHD, .
Adults even worse.

55 years ago I read studies that long distance runners and swimmers got the best grades in college.
I thought this was obvious but this study talks like it is news.

Human body is designed to run barefoot and throw spears at noon in hot weather --- the human niche in the ecosystem - that people can do better than all animals.



Leg exercise is critical to brain and nervous system health

In a new take on the exercise truism 'use it, or lose it,' researchers show neurological health is an interactive relationship with our muscles and our world


Groundbreaking research shows that neurological health depends as much on signals sent by muscles to the brain as it does on signals from the brain to the muscles.

Published today in Frontiers in Neuroscience, the study fundamentally alters brain and nervous system medicine   giving doctors new clues as to why patients with motor neuron disease, multiple sclerosis, spinal muscular atrophy and other neurological diseases often rapidly decline when their movement becomes limited.

"Our study supports the notion that
people who are unable to do load-bearing exercises
-- such as patients who are bed-ridden, or astronauts on extended travel   not only lose muscle mass, but their body chemistry is altered at the cellular level and even their nervous system is adversely impacted, 

The study involved restricting mice from using their hind legs, but not their front legs, over a period of 28 days.

The mice continued to eat and groom normally and did not exhibit stress.
At the end of the trial,
the researchers examined an area of the brain called the sub-ventricular zone, which in many mammals has the role of maintaining nerve cell health.
It is also the area where neural stem cells produce new neurons.

Limiting physical activity decreased the number of neural stem cells by 70 percent compared to a control group of mice, which were allowed to roam.

Furthermore, both neurons and oligodendrocytes -- specialized cells that support and insulate nerve cells   didn't fully mature when exercise was severely reduced.

The research shows that using the legs, particularly in weight-bearing exercise, sends signals to the brain that are vital for the production of healthy neural cells, essential for the brain and nervous system.

Cutting back on exercise makes it difficult for the body to produce new nerve cells   some of the very building blocks that allow us to handle stress and adapt to challenge in our lives.

"It is no accident that we are meant to be active:
to walk, run, crouch to sit, and use our leg muscles to lift things, 

"Neurological health is not a one-way street with the brain telling the muscles 'lift,' 'walk,' and so on."

The researchers gained more insight by analyzing individual cells.
They found that restricting exercise lowers the amount of oxygen in the body, which creates an anaerobic environment and alters metabolism.

Reducing exercise also seems to impact two genes, one of which, CDK5Rap1, is very important for the health of mitochondria
-- the cellular powerhouse that releases energy the body can then use.
This represents another feedback loop.

These results shed light on several important health issues, ranging from concerns about cardio-vascular impacts as a result of sedentary lifestyles to insight into devastating diseases, such as spinal muscular atrophy (SMA), multiple sclerosis, and motor neuron disease, among others.

"I have been interested in neurological diseases since 2004," says co-author Dr. Daniele Bottai, also from the Universita` degli Studi di Milano.

"The question I asked myself was: is the outcome of these diseases due exclusively to the lesions that form on the spinal cord in the case of spinal cord injury and genetic mutation in the case of SMA, or is the lower capacity for movement the critical factor that exacerbates the disease?"

This research demonstrates the critical role of movement and has a range of potential implications.

For example, missions to send astronauts into space for months or even years should keep in mind that gravity and load-bearing exercise play an important role in maintaining human health, say the researchers.

"One could say our health is grounded on Earth in ways we are just beginning to understand,"


Please include a link to the original research in your reporting:

Frontiers is an award-winning Open Science platform and leading open-access scholarly publisher.

Our mission is to make high-quality, peer-reviewed research articles rapidly and freely available to everybody in the world.

Monday, May 28, 2018

1918 flu pandemic - Wikipedia

1918 flu pandemic - Wikipedia

1918 flu pandemic

The 1918 flu pandemic (January 1918 – December 1920), also known as the Spanish flu, was an unusually deadly influenza pandemic, the first of the two pandemics involving H1N1 influenza virus.[1] It infected 500 million people around the world,[2] including people on remote Pacific islands and in the Arctic, and resulted in the deaths of 50 to 100 million (three to five percent of the world's population),[3] making it one of the deadliest natural disasters in human history.[4][5][6]

Disease had already greatly limited life expectancy in the early 20th century. In the first year of the pandemic, life expectancy in the United States dropped by about 12 years.[7][8][9] Most influenza outbreaks disproportionately kill juvenile, elderly, or already weakened patients; in contrast, the 1918 pandemic predominantly killed previously healthy young adults.[10]

There are several possible explanations for the high mortality rate of the 1918 influenza pandemic. Some research suggests that the specific variant of the virus had an unusually aggressive nature. One group of researchers recovered the virus from the bodies of frozen victims, and found that transfection in animals caused a rapid progressive respiratory failure and death through a cytokine storm (overreaction of the body's immune system). It was then postulated that the strong immune reactions of young adults ravaged the body, whereas the weaker immune systems of children and middle-aged adults resulted in fewer deaths among those groups.[11]

More recent investigations, mainly based on original medical reports from the period of the pandemic,[12][13] found that the viral infection itself was not more aggressive than any previous influenza, but that the special circumstances (malnourishment, overcrowded medical camps and hospitals, poor hygiene) promoted bacterial superinfection that killed most of the victims typically after a somewhat prolonged death bed.[14][15]

Historical and epidemiological data are inadequate to identify the pandemic's geographic origin.[2] It was implicated in the outbreak of encephalitis lethargica in the 1920s.[16]

To maintain morale, wartime censors minimized early reports of illness and mortality in Germany, the United Kingdom, France, and the United States.[17][18] Papers were free to report the epidemic's effects in neutral Spain (such as the grave illness of King Alfonso XIII).[19] This created a false impression of Spain as especially hard hit,[20] thereby giving rise to the pandemic's nickname, "Spanish Flu".[21]


Hypotheses about source

Historian Alfred W. Crosby recorded that the flu originated in the U.S. state of Kansas,[22] and popular writer John Barry echoed Crosby in describing Haskell County, as the point of origin[23] although already in late 1917 there had been a first wave in at least 14 US military camps.[24]

Investigative work in 1999 by a British team led by virologist John Oxford[25] of St Bartholomew's Hospital and the Royal London Hospital identified the major troop staging and hospital camp in Étaples, France, as being the center of the 1918 flu pandemic. In late 1917, military pathologists reported the onset of a new disease with high mortality that they later recognized as the flu. The overcrowded camp and hospital — which treated thousands of victims of chemical attacks and other casualties of war — was an ideal site for the spreading of a respiratory virus; 100,000 soldiers were in transit every day. It also was home to a live piggery, and poultry was regularly brought in from surrounding villages. Oxford and his team postulated that a significant precursor virus, harbored in birds, mutated so it could migrate to pigs that were kept near the front.[26][27]

Earlier hypotheses of the epidemic's origin have varied. Some hypothesized the flu originated in East Asia.[28] Claude Hannoun, the leading expert on the 1918 flu for the Pasteur Institute, asserted the former virus was likely to have come from China, mutating in the United States near Boston and spreading to Brest, France, Europe's battlefields, Europe, and the world using Allied soldiers and sailors as main spreaders.[29] He considered several other hypotheses of origin, such as Spain, Kansas, and Brest, as being possible, but not likely.

Political scientist Andrew Price-Smith published data from the Austrian archives suggesting the influenza had earlier origins, beginning in Austria in early 1917.[30]

In 2014, historian Mark Humphries of the Memorial University of Newfoundland in St. John's stated that newly unearthed records confirmed that one of the side stories of the war, the mobilization of 96,000 Chinese laborers to work behind the British and French lines on World War I's western front, might have been the source of the pandemic. In the report, Humphries found archival evidence that a respiratory illness that struck northern China in November 1917 was identified a year later by Chinese health officials as identical to the "Spanish" flu.[31][32] A report published in 2016 in the Journal of the Chinese Medical Association found no evidence that the 1918 virus was imported to Europe via Chinese and Southeast Asian soldiers and workers. It found evidence that the virus had been circulating in the European armies for months and possibly years before the 1918 pandemic.[33]


When an infected person sneezes or coughs, more than half a million virus particles can be spread to those close by.[34] The close quarters and massive troop movements of World War I hastened the pandemic, and probably both increased transmission and augmented mutation; the war may also have increased the lethality of the virus. Some speculate the soldiers' immune systems were weakened by malnourishment, as well as the stresses of combat and chemical attacks, increasing their susceptibility.[35]

A large factor in the worldwide occurrence of this flu was increased travel. Modern transportation systems made it easier for soldiers, sailors, and civilian travelers to spread the disease.[36]

In the United States, the disease was first observed in Haskell County, Kansas, in January 1918, prompting local doctor Loring Miner to warn the U.S. Public Health Service's academic journal. On 4 March 1918, company cook Albert Gitchell reported sick at Fort Riley, an American military facility that at the time was training American troops during World War I, making him the first recorded victim of the flu.[37][38] Within days, 522 men at the camp had reported sick.[39] By 11 March 1918, the virus had reached Queens, New York.[40] Failure to take preventive measures in March/April was later criticised.[5]

In August 1918, a more virulent strain appeared simultaneously in Brest, France; in Freetown, Sierra Leone; and in the U.S. in Boston, Massachusetts. The Spanish flu also spread through Ireland, carried there by returning Irish soldiers. The Allies of World War I came to call it the Spanish flu, primarily because the pandemic received greater press attention after it moved from France to Spain in November 1918. Spain was not involved in the war and had not imposed wartime censorship.[41]


Around the globe

The difference between the influenza mortality age-distributions of the 1918 epidemic and normal epidemics – deaths per 100,000 persons in each age group, United States, for the interpandemic years 1911–1917 (dashed line) and the pandemic year 1918 (solid line)[42]

The global mortality rate from the 1918/1919 pandemic is not known, but an estimated 10% to 20% of those who were infected died. With about a third of the world population infected, this case-fatality ratio means 3% to 6% of the entire global population died.[2] Influenza may have killed as many as 25 million people in its first 25 weeks. Older estimates say it killed 40–50 million people,[4] while current estimates say 50–100 million people worldwide were killed.[44]

This pandemic has been described as "the greatest medical holocaust in history" and may have killed more people than the Black Death.[45] It is said that this flu killed more people in 24 weeks than AIDS killed in 24 years, and more in a year than the Black Death killed in a century.[11] However, a 2016 article in The Atlantic states that the Black Death, over the course of the decade of the 1340s, killed more than 10% of the world population whereas the 1918 flu pandemic killed less than half this percentage.[46]

The disease killed in every corner of the globe. As many as 17 million died in India, about 5% of the population.[47] The death toll in India's British-ruled districts alone was 13.88 million.[48]

In Japan, of the 23 million people who were affected, 390,000 died.[49] In the Dutch East Indies (now Indonesia), 1.5 million were assumed to have died among 30 million inhabitants.[50] In Tahiti 13% of the population died during only a month. Similarly, in Samoa 22% of the population of 38,000 died within two months.[51]

In Iran, the impact was enormous and according to an estimate, between 902,400 and 2,431,000 or 8.0% and 21.7% of the total population died.[52]

In the U.S., about 28% of the population became infected, and 500,000 to 675,000 died.[53] Native American tribes were particularly hard hit. In the Four Corners area alone, 3,293 deaths were registered among Native Americans.[54] Entire village communities perished in Alaska.[55] In Canada 50,000 died.[56] In Brazil 300,000 died, including president Rodrigues Alves.[57] In Britain, as many as 250,000 died; in France, more than 400,000.[58] In West Africa an influenza epidemic killed at least 100,000 people in Ghana.[59] Tafari Makonnen (the future Haile Selassie, Emperor of Ethiopia) was one of the first Ethiopians who contracted influenza but survived,[60][61] although many of his family's subjects did not; estimates for the fatalities in the capital city, Addis Ababa, range from 5,000 to 10,000, or higher.[62] In British Somaliland one official estimated that 7% of the native population died.[63]

This huge death toll was caused by an extremely high infection rate of up to 50% and the extreme severity of the symptoms, suspected to be caused by cytokine storms.[4] Symptoms in 1918 were so unusual that initially influenza was misdiagnosed as dengue, cholera, or typhoid. One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the nose, stomach, and intestine. Bleeding from the ears and petechial hemorrhages in the skin also occurred".[44] The majority of deaths were from bacterial pneumonia,[64][65] a common secondary infection associated with influenza, but the virus also killed people directly, by causing massive hemorrhages and edema in the lung.[65]

The unusually severe disease killed up to 20% of those infected, as opposed to the usual flu epidemic mortality rate of 0.1%.[2][44]

Patterns of fatality

The pandemic mostly killed young adults. In 1918–1919, 99% of pandemic influenza deaths in the U.S. occurred in people under 65, and nearly half in young adults 20 to 40 years old. In 1920, the mortality rate among people under 65 had decreased sixfold to half the mortality rate of people over 65, but still 92% of deaths occurred in people under 65.[66] This is unusual, since influenza is normally most deadly to weak individuals, such as infants (under age two), the very old (over age 70), and the immunocompromised. In 1918, older adults may have had partial protection caused by exposure to the 1889–1890 flu pandemic, known as the Russian flu.[67] According to historian John M. Barry, the most vulnerable of all – "those most likely, of the most likely", to die – were pregnant women. He reported that in thirteen studies of hospitalized women in the pandemic, the death rate ranged from 23% to 71%.[68] Of the pregnant women who survived childbirth, over one-quarter (26%) lost the child.[69]

Another oddity was that the outbreak was widespread in the summer and autumn (in the Northern Hemisphere); influenza is usually worse in winter.[70]

Modern analysis has shown the virus to be particularly deadly because it triggers a cytokine storm, which ravages the stronger immune system of young adults.[23]

In fast-progressing cases, mortality was primarily from pneumonia, by virus-induced pulmonary consolidation. Slower-progressing cases featured secondary bacterial pneumonias, and there may have been neural involvement that led to mental disorders in some cases. Some deaths resulted from malnourishment.

A study – conducted by He et al. – used a mechanistic modelling approach to study the three waves of the 1918 influenza pandemic. They tried to study the factors that underlie variability in temporal patterns, and the patterns of mortality and morbidity. Their analysis suggests that temporal variations in transmission rate provide the best explanation and the variation in transmission required to generate these three waves is within biologically plausible values.[71]

Another study by He et al. used a simple epidemic model, to incorporate three factors including school opening and closing, temperature changes over the course of the outbreak, and human behavioral changes in response to the outbreak to infer the cause of the three waves of the 1918 influenza pandemic. Their modelling results showed that all three factors are important but human behavioral responses showed the largest effects.[72]

Deadly second wave

The second wave of the 1918 pandemic was much deadlier than the first. The first wave had resembled typical flu epidemics; those most at risk were the sick and elderly, while younger, healthier people recovered easily. But in August, when the second wave began in France, Sierra Leone and the United States,[73] the virus had mutated to a much deadlier form. As the American Experience Influenza 1918 episode says, October 1918 was the deadliest month of the whole pandemic.[citation needed]

This increased severity has been attributed to the circumstances of the First World War.[74] In civilian life, natural selection favors a mild strain. Those who get very ill stay home, and those mildly ill continue with their lives, preferentially spreading the mild strain. In the trenches, natural selection was reversed. Soldiers with a mild strain stayed where they were, while the severely ill were sent on crowded trains to crowded field hospitals, spreading the deadlier virus. The second wave began and the flu quickly spread around the world again. Consequently, during modern pandemics health officials pay attention when the virus reaches places with social upheaval (looking for deadlier strains of the virus).[75]

The fact that most of those who recovered from first-wave infections were now immune showed that it must have been the same strain of flu. This was most dramatically illustrated in Copenhagen, which escaped with a combined mortality rate of just 0.29% (0.02% in the first wave and 0.27% in the second wave) because of exposure to the less-lethal first wave.[76] On the rest of the population it was far more deadly now; the most vulnerable people were those like the soldiers in the trenches – young previously healthy adults.[77]

Devastated communities

Even in areas where mortality was low, so many were incapacitated that much of everyday life was hampered. Some communities closed all stores or required customers to leave orders outside. There were reports that health-care workers could not tend the sick nor the gravediggers bury the dead because they too were ill. Mass graves were dug by steam shovel and bodies buried without coffins in many places.[78]

Several Pacific island territories were particularly hard-hit. The pandemic reached them from New Zealand, which was too slow to implement measures to prevent ships carrying the flu from leaving its ports. From New Zealand, the flu reached Tonga (killing 8% of the population), Nauru (16%) and Fiji (5%, 9,000 people).[79]

Worst affected was German Samoa, today the independent state of Samoa, which had been occupied by New Zealand in 1914. 90% of the population was infected; 30% of adult men, 22% of adult women and 10% of children died. By contrast, the flu was kept away from American Samoa when Governor John Martin Poyer imposed a blockade.[79] In New Zealand itself, 8,573 deaths were attributed to the 1918 pandemic influenza, resulting in a total population fatality rate of 0.74%.[80] In Ireland, the Spanish Flu accounted for 10% of the total deaths in 1918.

Data analysis revealed 6,520 recorded deaths in Savannah-Chatham County, Georgia (population = 83,252) for the three-year period from January 1, 1917, to December 31, 1919. Of these deaths, influenza was specifically listed as the cause of death in 316 cases, representing 4.85 percent of all causes of death for the total time period.[81]

Less-affected areas

In Japan, 257,363 deaths were attributed to influenza by July 1919, giving an estimated 0.425% mortality rate, much lower than nearly all other Asian countries for which data are available. The Japanese government severely restricted maritime travel to and from the home islands when the pandemic struck.

In the Pacific, American Samoa[82] and the French colony of New Caledonia[83] also succeeded in preventing even a single death from influenza through effective quarantines. In Australia, nearly 12,000 perished.[84]

By the end of the pandemic, the isolated island of Marajó, in Brazil's Amazon River Delta had not reported an outbreak.[85]

Saint Helena also reported no deaths.[86]

Aspirin poisoning

In a 2009 paper published in the journal Clinical Infectious Diseases, Karen Starko proposed that aspirin poisoning contributed substantially to the fatalities. She based this on the reported symptoms in those dying from the flu, as reported in the post mortem reports still available, and also the timing of the big "death spike" in October 1918 which happened right after the Surgeon General of the United States Army, and the Journal of the American Medical Association both recommended very large doses of 8 to 31 grams of aspirin per day. These levels will produce hyperventilation in 33% of patients, as well as lung edema in 3% of patients.[87] Starko also points out that many early deaths showed "wet," sometimes hemorrhagic lungs, whereas late deaths showed bacterial pneumonia. She suggests that the wave of aspirin poisonings was due to a "perfect storm" of events: Bayer's patent on aspirin expired, so that many companies rushed in to make a profit and greatly increased the supply; this coincided with the flu pandemic; and the symptoms of aspirin poisoning were not known at the time.[87]

As an explanation for the universally high mortality rate, this hypothesis was questioned in a letter to the journal published in April 2010 by Andrew Noymer and Daisy Carreon of the University of California, Irvine, and Niall Johnson of the Australian Commission on Safety and Quality in Health Care. They questioned this universal applicability given the high mortality rate in countries such as India, where there was little or no access to aspirin at the time compared to the rate where aspirin was plentiful.[88] They concluded that "the salicylate [aspirin] poisoning hypothesis [was] difficult to sustain as the primary explanation for the unusual virulence of the 1918–1919 influenza pandemic".[88] In response, Starko pointed to anecdotal evidence of aspirin use in India and argued that even if aspirin over-prescription had not contributed to the high Indian mortality rate, it could still have been a factor for other high rates in areas where other exacerbating factors present in India played less of a role.[89]

End of the pandemic

After the lethal second wave struck in late 1918, new cases dropped abruptly – almost to nothing after the peak in the second wave.[11] In Philadelphia, for example, 4,597 people died in the week ending 16 October, but by 11 November, influenza had almost disappeared from the city. One explanation for the rapid decline of the lethality of the disease is that doctors got better at preventing and treating the pneumonia that developed after the victims had contracted the virus, although John Barry stated in his book that researchers have found no evidence to support this.[23]

Another theory holds that the 1918 virus mutated extremely rapidly to a less lethal strain. This is a common occurrence with influenza viruses: there is a tendency for pathogenic viruses to become less lethal with time, as the hosts of more dangerous strains tend to die out[23] (see also "Deadly Second Wave", above).

Long-term impact

A 2006 study in the Journal of Political Economy found that "cohorts in utero during the pandemic displayed reduced educational attainment, increased rates of physical disability, lower income, lower socioeconomic status, and higher transfer payments compared with other birth cohorts."[90]


Academic Andrew Price-Smith has made the argument that the virus helped tip the balance of power in the later days of the war towards the Allied cause. He provides data that the viral waves hit the Central Powers before they hit the Allied powers, and that both morbidity and mortality in Germany and Austria were considerably higher than in Britain and France.[30]

In the United States, Britain and other countries, despite the relatively high morbidity and mortality rates that resulted from the epidemic in 1918–1919, the Spanish flu began to fade from public awareness over the decades until the arrival of news about bird flu and other pandemics in the 1990s and 2000s.[91] This has led some historians to label the Spanish flu a "forgotten pandemic".[22]

Various theories of why the Spanish flu was "forgotten" include the rapid pace of the pandemic, which killed most of its victims in the United States, for example, within a period of less than nine months, resulting in limited media coverage. The general population was familiar with patterns of pandemic disease in the late 19th and early 20th centuries: typhoid, yellow fever, diphtheria, and cholera all occurred near the same time. These outbreaks probably lessened the significance of the influenza pandemic for the public.[92] In some areas, the flu was not reported on, the only mention being that of advertisements for medicines claiming to cure it.[93]

In addition, the outbreak coincided with the deaths and media focus on the First World War.[94] Another explanation involves the age group affected by the disease. The majority of fatalities, from both the war and the epidemic, were among young adults. The deaths caused by the flu may have been overlooked due to the large numbers of deaths of young men in the war or as a result of injuries. When people read the obituaries, they saw the war or postwar deaths and the deaths from the influenza side by side. Particularly in Europe, where the war's toll was extremely high, the flu may not have had a great, separate, psychological impact, or may have seemed a mere extension of the war's tragedies.[66]

The duration of the pandemic and the war could have also played a role. The disease would usually only affect a certain area for a month before leaving, while the war, which most had initially expected to end quickly, had lasted for four years by the time the pandemic struck. This left little time for the disease to have a significant impact on the economy.

Regarding global economic effects, many businesses in the entertainment and service industries suffered losses in revenue, while the health care industry reported profit gains.[95]

Historian Nancy Bristow has argued that the pandemic, when combined with the increasing number of women attending college, contributed to the success of women in the field of nursing. This was due in part to the failure of medical doctors, who were predominantly men, to contain and prevent the illness. Nursing staff, who were predominantly women, felt more inclined to celebrate the success of their patient care and less inclined to identify the spread of the disease with their own work.[96]

In Spain, sources from the period explicitly linked the Spanish flu to the cultural figure of Don Juan. The nickname for the flu, the "Naples Soldier", was adopted from Federico Romero and Guillermo Fernández Shaw's operetta, The Song of Forgetting (La canción del olvido), the protagonist of which is a stock Don Juan type. Federico Romero, one of the librettists, quipped that the play's most popular musical number, Naples Soldier, was as catchy as the flu. Davis has argued the Spanish flu–Don Juan connection served a cognitive function, allowing Spaniards to make sense of their epidemic experience by interpreting it through a familiar template, namely the Don Juan story.[97]

Spanish flu research

Main article: Spanish flu research

The origin of the Spanish flu pandemic, and the relationship between the near-simultaneous outbreaks in humans and swine, have been controversial. One hypothesis is that the virus strain originated at Fort Riley, Kansas, in viruses in poultry and swine which the fort bred for food; the soldiers were then sent from Fort Riley around the world, where they spread the disease.[98] Similarities between a reconstruction of the virus and avian viruses, combined with the human pandemic preceding the first reports of influenza in swine, led researchers to conclude the influenza virus jumped directly from birds to humans, and swine caught the disease from humans.[99][100]

Others have disagreed,[101] and more recent research has suggested the strain may have originated in a nonhuman, mammalian species.[102] An estimated date for its appearance in mammalian hosts has been put at the period 1882–1913.[103] This ancestor virus diverged about 1913–1915 into two clades (or biological groups), which gave rise to the classical swine and human H1N1 influenza lineages. The last common ancestor of human strains dates to between February 1917 and April 1918. Because pigs are more readily infected with avian influenza viruses than are humans, they were suggested as the original recipients of the virus, passing the virus to humans sometime between 1913 and 1918.

An effort to recreate the 1918 flu strain (a subtype of avian strain H1N1) was a collaboration among the Armed Forces Institute of Pathology, the USDA ARS Southeast Poultry Research Laboratory and Mount Sinai School of Medicine in New York City. The effort resulted in the announcement (on 5 October 2005) that the group had successfully determined the virus's genetic sequence, using historic tissue samples recovered by pathologist Johan Hultin from a female flu victim buried in the Alaskan permafrost and samples preserved from American soldiers.[104]

On 18 January 2007, Kobasa et al. (2007) reported that monkeys (Macaca fascicularis) infected with the recreated flu strain exhibited classic symptoms of the 1918 pandemic, and died from a cytokine storm[105]—an overreaction of the immune system. This may explain why the 1918 flu had its surprising effect on younger, healthier people, as a person with a stronger immune system would potentially have a stronger overreaction.[106]

On 16 September 2008, the body of British politician and diplomat Sir Mark Sykes was exhumed to study the RNA of the flu virus in efforts to understand the genetic structure of modern H5N1 bird flu. Sykes had been buried in 1919 in a lead coffin which scientists hoped had helped preserve the virus.[107] The coffin was found to be split because of the weight of soil over it, and the cadaver was badly decomposed. Nonetheless, samples of lung and brain tissue were taken through the split, with the coffin remaining in situ in the grave during this process.[108]

In December 2008, research by Yoshihiro Kawaoka of the University of Wisconsin linked the presence of three specific genes (termed PA, PB1, and PB2) and a nucleoprotein derived from 1918 flu samples to the ability of the flu virus to invade the lungs and cause pneumonia. The combination triggered similar symptoms in animal testing.[109]

In June 2010, a team at the Mount Sinai School of Medicine reported the 2009 flu pandemic vaccine provided some cross-protection against the 1918 flu pandemic strain.[110]

One of the few things known for certain about the influenza in 1918 and for some years after was that it was, out of the laboratory, exclusively a disease of human beings.[111]

In 2013, the AIR Worldwide Research and Modeling Group "characterized the historic 1918 pandemic and estimated the effects of a similar pandemic occurring today using the AIR Pandemic Flu Model". In the model, "a modern day "Spanish flu" event would result in additional life insurance losses of between USD 15.3–27.8 billion in the United States alone", with 188,000–337,000 deaths in the United States.[112]

In popular culture

The 1995 film Outbreak,[113] the 2011 film Contagion and the 2013 film World War Z make reference to the pandemic.[114]

Twentieth-century fiction includes at least three novels with the flu pandemic as a major theme: Katherine Anne Porter's Pale Horse, Pale Rider, Thomas Mullen's The Last Town on Earth, and Thomas Wolfe's Look Homeward, Angel.

In the one-act play 1918 by Horton Foote (part of his Orphans' Home Cycle (1979)), the presence and threat of the flu (and the tragedy it ultimately causes) is a major element of the plot. The play was made into a film of the same title, released in 1985, which was subsequently edited for broadcast by PBS as the last part of the miniseries "The Story of A Marriage".


See also


Further reading

External links