Thursday, June 27, 2013
Evanescence‘s Amy Lee has become an idol for countless hopeful female singers, songwriters and pianists worldwide.The American songstress became rock’s most influential female with the release of the Evanescence breakthrough album ‘Fallen’ in 2003. Her performances on ‘Bring Me to Life,’ ‘My Immortal,’ ‘Call Me When You’re Sober’ and more hits have kept her in the limelight for a decade, with her gothic beauty and unmistakable talent rallying up a cult fan base rivaling almost any active musician today. After completing a heavy 2012 tour schedule, Lee is currently taking a bit of a break to “figure things out.”
Tuesday, June 25, 2013
Illinois is paying the price — in both cash and reputation — for years of ignored warnings about its pension crisis, the worst in the nation.Largely because of its unfunded retirement plans, Illinois has replaced longtime bottom-dweller California as having the lowest credit rating of any state. So when Illinois tries to borrow money, it faces the same problem as the spendthrift cousin: far higher interest rates.The states financial failings are so well-known, they have inspired a name on Wall Street — the "Illinois effect," a reference to the fact that cities, universities and other bond-issuing entities here must pay more in interest, even if they are responsible spenders.
Friday, June 21, 2013
Bikes are great transportation: cheap, fast, dependable, no gas, no smog, get exercise, views, fun
New York Times: The Dutch Prize Their Pedal Power, but a Sea of Bikes Swamps Their Capital.
Bicycles, the preferred means of travel, are clogging streets and overwhelming parking spaces in Amsterdam, causing some to say the unthinkable: There are too many bikes.
http://lewrockwell.com/faber/faber161.html *Marc Faber: People With Assets Are All Doomed* *by Jason Farrell* */Daily Reckoning /* When the always cheerful Dr. Marc Faber gave his midyear forecast to Barron’s, it was, as you might expect, predictably sunny. ‘People with assets are all doomed,’ he began, ‘because prices are grossly inflated globally for stocks, bonds and collectibles.’ Faber warns the Federal Reserves low interest rates could lead to a global crash. Faber acknowledged the Fed’s role in rising equity prices this year. And suggested the party wouldn’t last, due to the uneven flow of money through the economy. ‘I own equities, and I should thank Mr. Bernanke. The Fed has been flooding the system with money. The problem is the money doesn’t flow into the system evenly. It doesn’t increase economic activity and asset prices in concert. Instead, it creates dangerous excesses in countries and asset classes… ‘Now money is flowing into the high-end asset market – things like stocks, bonds, art, wine, jewelry and luxury real estate. The art auction houses are seeing record sales. Property prices in the Hamptons rose 35% last year. Sandy Weill [the former head of Citigroup] bought a Manhattan condominium in 2007 for $43.7 million. He sold it last year for $88 million.’ Faber amended his prediction last year that there would be a 20% correction last fall:‘We might be in the final acceleration phase now. The Standard & Poor’s 500 could rally to 1,750 or even 2,000 in the next month or two before collapsing.’ Faber gave readers some insight into his own portfolio: no US stocks, 25% gold, 25% non-US equities, including some Asian real estate. He noted he was ‘tempted to short the S&P or the Russell 2000.’He also owns several Japanese stocks, noting that ‘Japanese stocks made a generational low in 2012 and won’t go below that.’ To read Marc Faber is to be grimly aware of all the uncertainty in the world that could erupt at any time. Collapsing bond markets. Accelerating inflation. A Chinese economic implosion. Civil unrest. Even a pandemic, Faber suggested, could end this year’s equities rally. ‘I don’t know how the world will look in five years,’ Faber lamented ‘so I have heeded Ray Dalio’s advice to diversify.’ Peace,
"They who can give up essential liberty to obtain a little temporary safety, deserve neither liberty nor safety." (1775) Benjamin Franklin
Thursday, June 20, 2013
There is plenty of fish in the sea but that does not mean it is easy to catch, clean, and cook even one fish.
Just because the government collects data does not mean they are smart enough to do anything with it. There are many spectacular intelligence failures. Few if any successes. But there will be a lot of spending and waste. This will divert money away from science, much of which is very interesting and useful.
I have always been fascinated by difficult computational problems and intend to do a lot more on it. I am looking for the hardest problem that I think I can solve. Probably in the area of DNA genetics + foods and other products purchased + features of the environment + lifestyle => Obamacare health care spending. How to reprogram society for health and survival. The hardest problem is getting the data. I think I can do the math and computer architecture. My popular book will list some practical common sense suggestions that are more important but probably too controversial. People are irrational so they prefer to spend pounds on cures instead of an ounce of prevention.
I was walking with an IBM mainframe COBOL programmer from Kansas City. I hear that American Airlines and others have a huge facility in Kansas City. Every pilot, seat, plane, staff, customer, bill, travel agent, web sites, must somehow be planned carefully respecting the weather and other problems. Lots of detail code in Assembler. Has worked good for decades so they cannot change that code to modern computing systems. Scheduling requires difficult linear programming probably written in Fortran. Already been done so I will not be interested in it.
Very interesting article:
NYTimes: Sizing Up Big Data, Broadening Beyond the Internet
Internet companies were just the start. Virtually every field, from science to sports to public health, is being transformed by data-driven discovery and decision-making.
Wednesday, June 19, 2013
I also get curry powder from ethnic supermarket that also includes pepper and other spices that may be beneficial. http://en.wikipedia.org/wiki/Curry_powder
How Turmeric Reduces Oxidative Stress and Supports Your Brain and Heart
How Turmeric Reduces Oxidative Stress and Supports Your Brain and Heart
> Turmeric (active ingredient is curcumin at 5%) per Dr. Russell > Blaylock is one of the most powerful antioxidants known. As for pain > relief Turmeric has steroidal qualities. Even so called mainstream > sources such as the National Cancer Institute on their website concede > the anti tumor effect of Turmeric is large double blind studies.
> The NCI concedes that studies show Turmeric may actually cure > Leukemia. My Oncologist states that Turmeric is"good stuff."
> Turmeric is poorly absorbed through the stomach lining. Black > pepper will increase absorption and is sometimes sold as part of a > preparation. (Puritan Pride.com). I take a teaspoon full of Turmeric > with olive oil as oil will vastly increase absorption. Turmeric is > reasonably priced in capsules at the local drug store. I purchase > Turmeric in bulk for about $4.00 per pound from "My Spice Sage" online. > Turmeric is known in Asia as "Golden Queen."
> *From:* Bob
> Science confirms Turmeric as effective as 14 Drugs
> Sayer Ji
> Mon, 13 May 2013 15:48 CDT
> Description: > http://www.sott.net/image/image/s7/142576/medium/turmeric_drug_alternative_2_.jpg >
> Turmeric is one the most thoroughly researched plants in existence > today. Its medicinal properties and components (primarily /curcumin/ > ) have been the > subject of over 5600 peer-reviewed and published biomedical studies > . In fact, our > five-year long research project on this sacred plant > has > revealed over 600 potential preventive and therapeutic applications, > as well as 175 distinct beneficial physiological effects. This entire > database of 1,585 ncbi-hyperlinked turmeric abstracts can be > downloaded as a PDF at our Downloadable Turmeric Document > > page, and acquired either as a retail item or with 200 GMI-tokens, for > those of you who are already are members and receive them > automatically each month. >
> Given the sheer density of research performed on this remarkable > spice, it is no wonder that a growing number of studies have concluded > that it compares favorably to a variety of conventional medications, > including: >
> * *Lipitor/Atorvastatin(cholesterol medication)*: A 2008 study > published in the journal /Drugs in R & D /found that a > standardized preparation of curcuminoids from Turmeric compared > favorably to the drug atorvastatin (trade name Lipitor) on > endothelial dysfunction, the underlying pathology of the blood > vessels that drives atherosclerosis, in association with > reductions in inflammation and oxidative stress in type 2 diabetic > patients. [i]
> > [For addition curcumin and 'high cholesterol' research > - 8 > abstracts]
> * *Corticosteroids (steroid medications):* A 1999 study published in > the /journal Phytotherapy Research /found that the primary > polyphenol in turmeric, the saffron colored pigment known as > curcumin, compared favorably to steroids in the management of > chronic anterior uveitis, an inflammatory eye disease.[ii]
> > A 2008 study published in /Critical Care Medicine/ found that > curcumin compared favorably to the corticosteroid drug > dexamethasone in the animal model as an alternative therapy for > protecting lung transplantation-associated injury by
> down-regulating inflammatory genes.[iii]
> > An earlier 2003 study published in /Cancer Letters/ found the same > drug also compared favorably to dexamethasone in a lung > ischaemia-repurfusion injury model.[iv]
> > [for additional curcumin and inflammation
> research > - 52 abstracts]
> * *Prozac/Fluoxetine & Imipramine (antidepressants):* A 2011 study > published in the journal /Acta Poloniae Pharmaceutica/ found that > curcumin compared favorably to both drugs in reducing depressive > behavior in an animal model.[v]
> > [for additional curcumin and depression
> > research - 5 abstracts]
> * *Aspirin (blood thinner):* A 1986 in vitro and ex vivo study > published in the journal /Arzneimittelforschung/ found that > curcumin has anti-platelet and prostacyclin modulating effects > compared to aspirin, indicating it may have value in patients > prone to vascular thrombosis and requiring anti-arthritis > therapy.[vi]
> > [for additional curcumin and anti-platelet
> > research]
> * *Anti-inflammatory Drugs*: A 2004 study published in the journal > /Oncogene/ found that curcumin (as well as resveratrol) were > effective alternatives to the drugs *aspirin, ibuprofen, sulindac, > phenylbutazone, naproxen, indomethacin, diclofenac, dexamethasone, > celecoxib, and tamoxifen* in exerting anti-inflammatory and > anti-proliferative activity against tumor cells.[vii]
> > [for additional curcumin and anti-proliferative
> > research - 15 abstracts]
> * *Oxaliplatin (chemotherapy drug)*: A 2007 study published in the > /International Journal of Cancer/ found that curcumin compares > favorably with oxaliplatin as an antiproliferative agenet in > colorectal cell lines.[viii]
> > [for additional curcumin and colorectal cancer
> > research - 52 abstracts]
> * *Metformin (diabetes drug)*: A 2009 study published in the journal > /Biochemitry and Biophysical Research Community /explored how > curcumin might be valuable in treating diabetes, finding that it > activates AMPK (which increases glucose uptake) and suppresses > gluconeogenic gene expression (which suppresses glucose production > in the liver) in hepatoma cells. Interestingly, they found > curcumin to be 500 times to 100,000 times (in the form known as > tetrahydrocurcuminoids(THC)) more potent than metformin in > activating AMPK and its downstream target acetyl-CoA carboxylase > (ACC). [ix]
> Another way in which turmeric and its components reveal their > remarkable therapeutic properties is in research on drug resistant-
> and multi-drug resistant cancers. We have two sections on our site > dedicated to researching natural and *integrative therapies > * > on these topics, and while there are dozens of substances with > demonstrable efficacy against these chemotherapy- and > radiation-resistant cancers, curcumin tops both lists: >
> * *Cancers: Drug Resistant
> * > * *Cancers: Multi-Drug Resistant
> * >
> We have found no less than 54 studies indicating that curcumin can > induce cell death or sensitize drug-resistant cancer cell lines to > conventional treatment.[x] > > >
> We have identified 27 studies on curcumin's ability to either induce > cell death or sensitize multi-drug resistant cancer cell lines to > conventional treatment.[xi] > > >
> Considering how strong a track record turmeric (curcumin) has, having > been used as both food and medicine in a wide range of cultures, for > thousands of years, a strong argument can be made for using curcumin > as a drug alternative or adjuvant in cancer treatment. >
> Or, better yet, use certified organic (non-irradiated) turmeric in > lower culinary doses on a daily basis so that heroic doses won't be > necessary later in life after a serious disease sets in. Nourishing > yourself, rather than self-medicating with 'nutraceuticals,' should be > the goal of a healthy diet. [learn more at Sayer Ji's new > collaborative project EATomology ] >
> * [i] P Usharani, A A Mateen, M U R Naidu, Y S N Raju, Naval > Chandra. Effect of NCB-02, atorvastatin and placebo on endothelial > function, oxidative stress and inflammatory markers in patients > with type 2 diabetes mellitus: a randomized, parallel-group, > placebo-controlled, 8-week study.
> > Drugs R D. 2008;9(4):243-50. PMID: 18588355
> * [ii] B Lal, A K Kapoor, O P Asthana, P K Agrawal, R Prasad, P > Kumar, R C Srimal. Efficacy of curcumin in the management of > chronic anterior uveitis.
> > /Phytother Res./ 1999 Jun;13(4):318-22. PMID: 10404539
> * [iii] Jiayuan Sun, Weigang Guo, Yong Ben, Jinjun Jiang, Changjun > Tan, Zude Xu, Xiangdong Wang, Chunxue Bai. Preventive effects of > curcumin and dexamethasone on lung transplantation-associated lung > injury in rats.
> > /Crit Care Med/. 2008 Apr;36(4):1205-13. PMID: 18379247
> * [iv] J Sun, D Yang, S Li, Z Xu, X Wang, C Bai. Effects of curcumin > or dexamethasone on lung ischaemia-reperfusion injury in rats.
> > /Cancer Lett./ 2003 Mar 31;192(2):145-9. PMID: 18799504
> * [v] Jayesh Sanmukhani, Ashish Anovadiya, Chandrabhanu B Tripathi. > Evaluation of antidepressant like activity of curcumin and its > combination with fluoxetine and imipramine: an acute and chronic > study.
> /Acta > Pol Pharm/. 2011 Sep-Oct;68(5):769-75. PMID: 21928724
> * [vi] R Srivastava, V Puri, R C Srimal, B N Dhawan. Effect of > curcumin on platelet aggregation and vascular prostacyclin > synthesis.
> > Arzneimittelforschung. 1986 Apr;36(4):715-7. PMID: 3521617
> * [vii] Yasunari Takada, Anjana Bhardwaj, Pravin Potdar, Bharat B > Aggarwal. Nonsteroidal anti-inflammatory agents differ in their > ability to suppress NF-kappaB activation, inhibition of expression > of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell > proliferation.
> > /Oncogene/. 2004 Dec 9;23(57):9247-58. PMID: 15489888
> * [viii] Lynne M Howells, Anita Mitra, Margaret M Manson. Comparison > of oxaliplatin- and curcumin-mediated antiproliferative effects in > colorectal cell lines.
> > /Int J Cancer./ 2007 Jul 1;121(1):175-83. PMID: 17330230
> * [ix] Teayoun Kim, Jessica Davis, Albert J Zhang, Xiaoming He, > Suresh T Mathews. Curcumin activates AMPK and suppresses > gluconeogenic gene expression in hepatoma cells.
> > /Biochem Biophys Res Commun./ 2009 Oct 16;388(2):377-82. Epub 2009 > Aug 8. PMID: 19665995
> * [x] GreenMedInfo.com, Curcumin Kills Drug Resistant Cancers, > > 54 Abstracts
> * [xi] GreenMedInfo.com, Curcumin Kills Multi-Drug Resistant Cancers
> : > 27 Abstracts.
Tuesday, June 18, 2013
> http://washingtonexaminer.com/lights-out-house-plan-would-protect-nations-electricity-from-solar-flare-nuclear-bomb/article/2532038 > > > Lights out: House plan would protect nation's electricity from solar > flare, nuclear bomb > > Photo - > > > Photo - AP Photo/NASA Solar Dynamics Observatory This blend of two > images taken by NASA's Solar Dynamics Observatory shows a solar > eruption that occurred on May 12. Scientists say the Mother's Day > solar flare was the strongest of the year and occurred on the side of > the sun that faced away from Earth. > AP > Photo/NASA Solar Dynamics Observatory This blend of two images taken > by NASA's Solar Dynamics... > > Amid growing fears of a massive electromagnetic pulse hit from either > a solar flare or a terrorist nuclear bomb, House Republicans on > Tuesday will unveil a plan to save the nation's electric grid from an > attack that could mean lights out for 300 million Americans. > > Dubbed the Secure High-voltage Infrastructure for Electricity from > Lethal Damage Act, the legislation would push the federal government > to install grid-saving devices such as surge protectors to protect > against an attack. > > "It is critical that we protect our major transformers from cascading > destruction. The Shield Act encourages industry to develop standards > necessary to protect our electric infrastructure against both natural > and man-made EMP events," said Rep. Trent Franks, the Arizona > Republican who is offering up the bipartisan bill. > > Electromagnetic pulse, or EMP, has come into focus because of fears > the sun is pushing out unusually big solar flares that can disrupt the > electric grid. Defense officials are also worried about a terrorist > attack, possibly in the form of a small nuclear bomb exploded overhead. > > "This is serious stuff," said former Pentagon official Frank Gaffney > , who > heads the Center for Security Policy. But, he added, there is a > growing bipartisan consensus to protect the electric grid. > > Any EMP attack could be damaging, said Gaffney. He cited a new Lloyds > of London report that determined that the area from Washington, D.C., > to New York could be without electricity for up to two years in a > major solar flare-up. > > The legislation will be introduced Tuesday by Franks and former House > Speaker Newt Gingrich at a meeting of the House EMP Caucus. Officials > said that the legislation, provided in advance to Secrets, will > include information from a recent EMP commission report that > "contemporary U.S. society is not structured, nor does it have the > means, to provide for the needs of nearly 300 million Americans > without electricity.'' > > Gaffney told Secrets that there are some 300 huge electric > transformers around the nation that control the grid and that have to > be protected. "You are basically talking about surge protectors, of a > somewhat exotic kind, but it is a means of interrupting the pulse," he > said >
Monday, June 17, 2013
Sunday, June 16, 2013
http://bits.blogs.nytimes.com/2013/06/11/google-expands-its-boundaries-buying-waze-for-1-billion/ http://techcrunch.com/2013/06/11/its-official-google-buys-waze-giving-a-social-data-boost-to-its-location-and-mapping-business/ After months of speculation, the fate ofWaze , the social-mapping-location-data startup, is finally decided: Google isbuying the company , giving the search giant a social boost to its already-strong mapping and mobile businesses. Speculation has had the sale at $1 billion to $1.3 billion, and so far there is no price on the deal, but a source tells TechCrunch that it was done for $1.1 billion. *Update*: Waze has alsopublished a blog post on the acquisition. In it, CEO Noam Bardin writes that CEO Larry Page, Google GEO VP Brian McClendon and the Google Maps teams “We are excited about the prospect of working with the Google Maps team to enhance our search capabilities and to join them in their ongoing efforts to build the best map of the world.” He also notes that “nothing practical will change,” with the company, now pushing 50 million users, “will maintain our community, brand, service and organization.” He also raises the subject of why Waze decided to sell. Bardin says that it was motivated by the fact that an IPO appeared the route that would take the company more into being focused on returns and less on growing as a product for users. “Choosing the path of an IPO often shifts attention to bankers, lawyers and the happiness of Wall Street, and we decided we’d rather spend our time with you, the Waze community.” Of course, the burden of getting a return on the investment now become’s Google’s, but as you can see below there are a number of reasons why it would buy Waze, anyway.
Saturday, June 15, 2013
Friday, June 14, 2013
Hippocrates once said, "Illnesses do not come upon us out of the blue. They are developed from small daily sins against Nature. When enough sins have accumulated, illnesses will suddenly appear."
http://www.kurzweilai.net/billion-euro-brain-simulation-and-graphene-projects-win-european-funds Billion-euro brain simulation and graphene projects win European funds
January 24, 2013 Neocortical column studied in Henry Markram’s Blue Brain project (Credit: Ecole Polytechnique Fédérale de Lausanne) The European Commission has selected the two research proposals it will fund to the tune of half-a-billion euros ($650 million U.S.) each, after a two-year, high-profile contest, /Nature News/ reports . The Human Brain Project, led by neuroscientist Henry Markram at the Swiss Federal Institute of Technology (EPFL) in Lausanne, plans to simulate the human brain in a supercomputer. (See “Brain in a box ”). The other project, called Graphene, is led by theoretical physicist Jari Kinaret at Chalmers University of Technology in Gothenburg, Sweden. It will develop the potential of graphene — an ultrathin, flexible and conducting form of carbon — along with related materials for applications in computing, batteries and sensors. The projects expect to receive €1 billion ($1.3 billion) over ten years, half to be provided by the European Commission and half by participants. http://en.wikipedia.org/wiki/Blue_Brain_Project The *Blue Brain Project* is an attempt to create a synthetic brain by reverse-engineering the mammalian brain down to the molecular level. The aim of the project, founded in May 2005 by the Brain and Mind Institute of the /École Polytechnique Fédérale de Lausanne / (Switzerland) is to study the brain's architectural and functional principles. The project is headed by the Institute's director, Henry Markram . Using a Blue Gene supercomputer running Michael Hines's NEURON software , the simulation does not consist simply of an artificial neural network , but involves a biologically realistic model of neurons .^ ^ ^ It is hoped that it will eventually shed light on the nature of consciousness .^ There are a number of sub-projects, including the Cajal Blue Brain , coordinated by the Supercomputing and Visualization Center of Madrid (CeSViMa), and others run by universities and independent laboratories. Goals[edit ] Neocortical column modelling[edit ] The initial goal of the project, completed in December 2006,^ was the simulation of a rat neocortical column , which is considered by some researchers to be the smallest functional unit of the neocortex ^ ^ (the part of the brain thought to be responsible for higher functions such as conscious thought). Such a column is about 2 mm tall, has a diameter of 0.5 mm and contains about 60,000 neurons in humans; rat neocortical columns are very similar in structure but contain only 10,000 neurons (and 10^8 synapses ). Between 1995 and 2005, Markram mapped the types of neurons and their connections in such a column. Whole brain simulation[edit ] Main article: Whole brain emulation A longer term goal is to build a detailed, functional simulation of the physiological processes in the human brain: "It is not impossible to build a human brain and we can do it in 10 years," Henry Markram, director of the Blue Brain Project said in 2009 at the TED conference in Oxford.^ In a BBC World Service interview he said: "If we build it correctly it should speak and have an intelligence and behave very much as a human does."^ Cajal Blue Brain used theMagerit supercomputer (CeSViMa ) The Cajal Blue Brain^ is coordinated by the Technical University of Madrid and uses the facilities of the Supercomputing and Visualization Center of Madrid and its supercomputer Magerit . The Cajal Institute also participates in this collaboration. The main lines of research currently being pursued at Cajal Blue Brain include neurological experimentation and computer simulations. Nanotechnology, in the form of a newly designed brain microscope, plays an important role in its research plans.^ See also[edit ] * Artificial brain * Artificial intelligence * Artificial neural network * CoDi * Cognitive science * Human Brain Project (EU) * List of brain mapping topics and related * Neural network * Neuroinformatics * Project Joshua Blue * Simulation argument * Simulated reality * Social simulation * Whole brain emulation
Tuesday, June 11, 2013
Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer: Thomas Seyfried: 9780470584927: Amazon.com: Books
Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England formally St. Francis College and also holds a Masters degree in Genetics from Illinois State University, Normal, IL. Thomas Seyfried served with distinction in the United States Army First Cavalry Division during the Vietnam War, and received numerous medals and commendations including the Bronze Star, Air Medal, and Army Commendation Medal. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine, and then served on the faculty as an Assistant Professor in Neurology. Prior to receiving full professorship, Dr. Seyfried was an Associate Professor in the Department of Biology at Boston College. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro. Dr. Seyfrieds research program focuses on gene environmental interactions related to complex diseases, such as epilepsy, autism, brain cancer, and neurodegenerative the GM1 and GM2 gangliosidoses diseases. Dr. Seyfried investigates many of these diseases from the perspective of, genetics, lipidomics, and energy metabolism. Much of his work also has direct translational benefit to the clinic. A list of Dr. Seyfrieds recent publications appear on his website in the Boston College Biology Department http://www.bc.edu/schools/cas/biology/facadmin/seyfried.html
Sacramento UC Davis Symposium CalPERS environment. Water, air quality, pesticides, herbicides, fungicides, chemicals, fertilizers,
Monday, June 10, 2013
Sunday, June 9, 2013